Smoked tuna is one of traditional fisheries product in Tobelo, North Halmahera. Tobelos people like this product because of its smoke taste. In Tobelo, there are many producer who sell this product, but information about its quality was unknown. In this research, the researcher wants to know about microbiology aspect of smoked tuna from three traditional market in Tobelo. The result of this research showed that Total Plate Count (TPC) value was from 7,5x10¹5,35x10² APM/g; smoked tuna from modern Market showed the highest Staphulococcus sp. colony at 1,3x10³ CFU/g. colony of Salmonella sp. showed negative value for three different market. The highest fungy colony was 2,5x10¹ CFU/g from Gotong royong Market, for Escherichia coli analysis, smoked tuna from Gotong Royong Market showed high value at 23 CFU/g, it was exceed Indonesia National Standard.

Empirically, sea cucumber as a food ingredient that is believed to have efficacy as medicine (nutraceutical) because it contains bioactive compounds like terpenoid, saponin, essential amino acids, glycosaminglycan, chondroitin sulfate, sulfate polysaccharides, lectins, phenol and peptides. The aim of this research were to identify processing method performed by fisherman in Kakara Pulau and to determine the toxicity of dried sea cucumber extract againts Artemia salina larvae with three different solvents. The result showed that there were 8 types of sea cucumber that were dominant caught ny fisherman namely Kongkong, Joko, Susu, Kalengkong, Nanas, Benang, Badara dan Pasir. Most of them, process sea cucumber using a combination of smoking and drying. Based on the toxicity test, dried sea cucumber extract is included in the toxic category, which has the potential to be developed as an antibacterial.