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Efficacy of attenuated bacteria vaccine against streptococcal infection in larvae tilapia (Oreochromis niloticus)

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One of the common diseases found in tilapia is a streptococcal disease caused by the Streptococcus agalactiae bacteria. Treatment of this disease is generally done by using antibiotics.  The use of antibiotics in controlling disease in fish can create resistant bacterial strains with certain doses. The use of vaccines is one of the alternative control methods in fish defence against infections. The purpose of this study was to analyze the efficacy of vaccination on seeds through immersion using attenuated active bacteria to increase immunity at the beginning of the spread of streptococcosis disease. The vaccine used was obtained from attenuated Streptococcus agalactiae bacteria through repeated passage ten times. Vaccination was carried out through oral vaccine. Challenge tests were carried out on days 7, 14, and 21 days after vaccination on tilapia larvae by immersion. The result indicated that vaccination using attenuated bacteria could increase lysozyme activity at each observation time compared to control. The mortality of post-challenged larvae on days 7, 14 and 21 post-vaccination was lower than that of unvaccinated seed. The percentage of RPS values up to the 14th day of observation has increased and tends to decrease on the 21st day.


Attenuated vaccine
Streptococcal diseases


Funding Information

Indonesian Ministry of Research, Technology and Higher Education (Ristekdikti) to provide funding for this study (contract no. 6572/LL9/ KU.03.00/2021).

Publisher's Note

Sekolah Tinggi Ilmu Pertanian Wuna on behalf of SRM Publishing remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Data sharing not applicable to this article as no datasets were generated or analysed during the current study, and/or contains supplementary material, which is available to authorized users.


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Cite this article as:

Suryahman, A., Masriah, A., Nisaa, K., Rahmi, R., & Akmal, A., 2021. Efficacy of attenuated bacteria vaccine against streptococcal infection in larvae tilapia (Oreochromis niloticus). Akuatikisle: Jurnal Akuakultur, Pesisir dan Pulau-Pulau Kecil 5(2): 63-66. https://doi.org/10.29239/j.akuatikisle.5.2.63-66
  • Submitted
    10 November 2021
  • Revised
    16 November 2021
  • Accepted
    Not available
  • Published
    15 November 2021
  • Discipline(s)


Agus  Suryahman

AgusSuryahman Faculty of Fisheries, Cokroaminoto University of Makassar, Jl. Perintis Kemerdekaan KM 11, Makassar, South Sulawesi 90245, Indonesia. suryahmanagus@gmail.com

Andi  Masriah

AndiMasriah Faculty of Fisheries, Cokroaminoto University of Makassar, Jl. Perintis Kemerdekaan KM 11, Makassar, South Sulawesi 90245, Indonesia. andimasriah@gmail.com

Khairun  Nisaa

KhairunNisaa Faculty of Fisheries, Cokroaminoto University of Makassar, Jl. Perintis Kemerdekaan KM 11, Makassar, South Sulawesi 90245, Indonesia. nisauicha27@gmail.com, scholarGoogle Scholar Profile

Rahmi  Rahmi

RahmiRahmi Faculty of Agricultural, Muhammadiyah University of Makassar, Jl. Sultan Alauddin No.259 Makassar, South Sulawesi 90221, Indonesia. ammy_akl@yahoo.co.id

Akmal  Akmal

AkmalAkmal The Center for Brackish Water Aquaculture Takalar, Jl. Perikanan, Desa Mappakalompo, Kecamatan Galesong, Kabupaten Takalar, South Sulawesi 92254, Indonesia. akmal_bbaptakalar@yahoo.com

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